Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract

作者：Akacha Maroua; Lahbib Karima; Remadi Mejda Daami; Boughanmi Neziha Ghanem

来源：Bangladesh Journal of Pharmacology, 2016, 11(3): 666-674.

DOI：10.3329/bjp.v11i3.27000

<jats:p>&lt;p class="Abstract"&gt;The aim of the present study is to examine the antibacterial, antifungal and anti-inflammatory activities of the ethanolic leaf extract of &lt;em&gt;Melia azedarach&lt;/em&gt;. It was tested &lt;em&gt;in vitro &lt;/em&gt;for its antibacterial and antifungal activities against&lt;em&gt; E. coli &lt;/em&gt;(ATCC 8739), &lt;em&gt;Enterococcus faecalis (Ec P07)&lt;/em&gt; and &lt;em&gt;Bacillus subtilis (Bs)&lt;/em&gt; bacteria as well as against pathogenic fungi (&lt;em&gt;Alternaria alternate&lt;/em&gt;, &lt;em&gt;Fusarium solani,&lt;/em&gt; &lt;em&gt;Fusarium&lt;/em&gt; &lt;em&gt;oxysporum&lt;/em&gt; sp. &lt;em&gt;melonis, F. oxysporum&lt;/em&gt; f. sp. &lt;em&gt;lycopersici&lt;/em&gt;, &lt;em&gt;F. sambucinum &lt;/em&gt;and&lt;em&gt; &lt;/em&gt;&lt;em&gt;Botrytis cinerea&lt;/em&gt;) with different techniques similtaneously with anti-inflammatory activity with carageaneen method. All tested concentrations of &lt;em&gt;M. azedarach&lt;/em&gt; extract showed significant antibacterial and antifungal activities with low IC&lt;sub&gt;50&lt;/sub&gt; compared to ethanol 95% and a high anti-inflammatory activity compared with indomethacin as drug. Our investigation pointed that &lt;em&gt;M. azedarach&lt;/em&gt; could be considered as a good medicinal agent.&lt;/p&gt;&lt;p class="Abstract"&gt;&lt;strong&gt;Video Clip&lt;/strong&gt;&lt;/p&gt;&lt;p class="Abstract"&gt;&lt;a href="https://youtube.com/v/Pc51tGbuxQY"&gt;Anti-inflammatory effect:&lt;/a&gt; 3 min 03 sec &lt;/p&gt;&lt;script type="mce-text/javascript" &gt;&lt;/script&gt;&lt;script type="mce-text/javascript" &gt;&lt;/script&gt;</jats:p>

• 出版日期2016