Left Ventricular Stiffening as Therapeutic Target for Heart Failure With Preserved Ejection Fraction

作者：Sakata Yasushi^*; Ohtani Tomohito; Takeda Yasuharu; Yamamoto Kazuhiro; Mano Toshiaki

来源：Circulation Journal, 2013, 77(4): 886-892.

DOI：10.1253/circj.CJ-13-0214

• Diastolic dysfunction
• Heart failure
• Ventricular function

The high prevalence of patients with heart failure (HF) with preserved ejection fraction (HFpEF) has highlighted the pivotal role of diastolic function in the development of HF. Abnormalities of diastolic function induce elevated left ventricular (LV) end-diastolic pressure, which leads to pulmonary edema and the symptoms of HF because the LV, left atrium and the pulmonary veins form 1 chamber while the mitral valve is opening. Thus, LV diastolic dysfunction results in the development of HF, in particular, HFpEF. LV stiffness mainly contributes to the transition to HFpEF, but noninvasive assessment and the therapeutic strategy for LV stiffness have not been fully established. This review will focus on the contribution of LV passive stiffness to the development of HFpEF and on the evaluation and treatment of LV stiffening based on insights gained from a hypertensive HFpEF animal model we have developed. (Circ J 2013; 77: 886-892)

• 出版日期2013-4