Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro- 1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

作者:Papeo Gianluca; Posteri Helena; Borghi Daniela; Busel Alina A; Caprera Francesco; Casale Elena; Ciomei Marina; Cirla Alessandra; Corti Emiliana; D' Anello Matteo; Fasolini Marina; Forte Barbara; Galvani Arturo; Isacchi Antonella; Khvat Alexander; Krasavin Mikhail Y; Lupi Rosita; Orsini Paolo; Perego Rita; Pesenti Enrico; Pezzett Daniele; Rainoldi Sonia; Riccardi Sirtori Federico; Scolaro Alessandra; Sola Francesco; Zuccotto Fabio; Felder Eduard R
来源:Journal of Medicinal Chemistry, 2015, 58(17): 6875-6898.
DOI:10.1021/acs.jmedchem.5b00680