Detection of Human Immunodeficiency Virus (HIV) Type 1 M184V and K103N Minority Variants in Patients with Primary HIV Infection

作者：Toni Thomas A; Asahchop Eugene L; Moisi Daniela; Ntemgwa Michel; Oliveira Maureen; Masquelier Bernard; Brenner Bluma G; Wainberg Mark A^*

来源：Antimicrobial Agents and Chemotherapy, 2009, 53(4): 1670-1672.

DOI：10.1128/AAC.01494-08

We used an allele-specific real-time PCR assay to explore the presence of K103N and M184V minority species among primary human immunodeficiency virus (HIV) infections and their potential influence in HIV transmission. Thirty randomly chosen antiretroviral drug-naive patients lacking both the K103N and the M184V mutations as determined by conventional sequencing methods were studied, and K103N and M184V viral minority species were found in three (10%) and four (11%) patients, respectively.

• 出版日期2009-4