A Novel Method for the Preparation of a Chiral Stationary Phase Containing an Enantiopure Acridino-18-Crown-6 Ether Selector

作者：Nemeth Tamas; Levai Sandor; Fodi Tamas; Kupai Jozsef; Turos Gyoergy; Toth Tunde; Huszthy Peter; Balogh Gyoergy Tibor^*

来源：Journal of Chromatographic Science, 2015, 53(3): 431-435.

DOI：10.1093/chromsci/bmu157

This paper reports a novel method for the preparation of chiral stationary phases (CSPs) using an acridino-18-crown-6 ether selector as a model compound. Chiral stationary phase (R, R)-CSP-2A was obtained by in situ continuously recirculating the solution of carboxyl-substituted acridino-18-crown-6 ether (R, R)-4, dicyclohexylcarbodiimide and 3-(triethoxysilyl) propylamine through a high-performance liquid chromatography (HPLC) column containing blank silica gel in elevated pressure and temperature. The enantiomer separating ability of chiral stationary phase (R, R)-CSP-2A was investigated by HPLC using mixtures of enantiomers of 1-(1-naphthyl)ethylamine hydrogen perchlorate, 1-(2-naphthyl)ethylamine, 1-(4-bromophenyl)ethylamine and 1-(4-nitrophenyl)ethylamine hydrogen chloride. The best results were found for the separation of the mixtures of enantiomers of Br-PEA.

• 出版日期2015-3