alpha-Santalol derivatives from Santalum album and their cytotoxic activities

作者：Matsuo Yukiko^*; Mimaki Yoshihiro

来源：Phytochemistry, 2012, 77: 304-311.

DOI：10.1016/j.phytochem.2012.02.007

• Santalum album
• Santalaceae
• Sesquiterpene
• alpha-Santalol
• HL-60 cells
• Cytotoxicity

A bioassay-guided fractionation of the heartwood of Santalum album led to the isolation of seven alpha-santalol derivatives including (9S,10E)-9-hydroxy-alpha-santalal, (10R,11S)-10,11-dihydroxy-alpha-santalol, (9E)-11,13-dihydroxy-alpha-santalol, and (10E)-12-hydroxy-alpha-santalic acid. Their structures were determined on the basis of results of spectroscopic analysis, including two-dimensional (2D) NMR spectroscopic data. The isolated compounds and derivatives were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells and TIG-3 normal human diploid fibroblasts. Of these (9S,10E)-9-hydroxy-alpha-santalal, exhibited tumor-selective cytotoxicity. The apoptosis induction properties of sesquiterpenes with cytotoxic potency in HL-60 cells are also described.

• 出版日期2012-5