A screening test for capsaicin-stimulated salivary flow using filter paper: a study for diagnosis of hyposalivation with a complaint of dry mouth

作者：Kanehira Takashi; Yamaguchi Tomotaka; Asano Kozo; Morita Manabu; Maeshima Etsuko; Matsuda Akemi; Fujii Yoshihiro; Sakamoto Wataru^*

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2011, 112(1): 73-80.

DOI：10.1016/j.tripleo.2011.02.036

Objective. The purpose of this study was to develop a simple screening technique for diagnosis of hyposalivation with dry mouth by estimation of capsaicin-stimulated salivary flow using filter paper.
Study design. An assay system comprising 5 spots containing starch and potassium iodide on filter paper incorporating or without capsaicin and a coloring reagent was designed. We investigated whether the number of colored spots using the filter paper incorporating capsaicin could distinguish between healthy subjects and subjects with hyposalivation and dry mouth.
Results. In the healthy group (> 200 mu L/min; n = 33), the capsaicin-stimulated salivary flow significantly increased as compared with the resting salivary flow, from 1.2 +/- 1.4 to 2.9 +/- 1.3 colored spots (P <.05). In contrast, the hyposalivation group with dry mouth (< 100 mu L/min; n = 32) hardly changed (4.4 +/- 1.0 vs 4.9 +/- 0.2), except for 3 subjects who had considerable elevated secretion on capsaicin stimulation.
Conclusion. By measuring resting and stimulated salivary flows, this method should be useful for evaluating retained functional ability of salivary glands and screening of hyposalivation with dry mouth. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: 73-80)

• 出版日期2011-7