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摘要
The effects of miR-605 rs2043556 single nucleotide polymorphism (SNP) on the risk and prognosis of lung cancer are unclear. This study investigated the relationships between miR-605 rs2043556 and the susceptibility and overall survival (OS) of lung cancer in Chinese non-smoking females. This hospital-based case-control study included 450 cases and 450 controls. Also, a prospective cohort study was carried out, and the patients were followed up until February 29th, 2016. There were 334 patients with prognostic information. Odds ratio and hazard ratio (HR) and their 95% confidence intervals (CIs) were calculated, respectively. In squamous cell carcinomas (SqCC) patients, homozygous GG genotype carriers had a 2.157-fold elevated risk of lung cancer compared with homozygous AA genotype carriers after adjusting age (95% CI = 1.029-4.524, P = 0.042). After adjusting age, pathological type, clinical stage, chemotherapy and surgery, only a marginal significance was observed among the patients with GG genotype, who had a longer OS than those with AA genotype (HR = 0.632, 95% CI = 0.398-1.003, P = 0.051). For patients younger than 60 years, those containing GG genotype was independently associated with OS (HR = 0.511, 95% CI = 0.268-0.977, P = 0.042). Patients with adenocarcinomas containing GG genotype was independently associated with OS (HR = 0.530, 95% CI = 0.312-0.898, P = 0.018). MiR-605 rs2043556 polymorphism could be associated with the susceptibility of SqCC in northeast Chinese non-smoking females. Age and pathological type might have the potential to modify the association between miR-605 rs2043556 and the OS of non-smoking female lung cancer patients.
