A novel chloro-substituted pentenamide from the fruiting bodies of Amanita virgineoides

作者：Liu, Liang-Yan; Liu, Ji-Kai^*; Su, Wen-Han; Peng, Tao

来源：Journal of Asian Natural Products Research, 2018, 20(1): 86-91.

DOI：10.1080/10286020.2017.1367771

• Amanita virgineoides
• (3R)-4-chloro-3-hydroxy-4-pentenamide
• ergosterol
• antiviral activity

One unusual chloro-substituted pentenamide, (3R)-4-chloro-3-hydroxy-4-pentenamide (1), together with 11 known compounds (2-12) were isolated from the fruiting bodies of Amanita virgineoides. The structure of 1 including the absolute configuration was characterized by extensive spectroscopic analyses and quantum calculation. Compound 1 displayed no obvious activity against herpes simplex virus (HSV), human enterovirus 71 (EV71) or coxsackievirus B3 (CVB3).
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• 出版日期2018
• 单位中国科学院; 中国科学院广州生物医药与健康研究院; 云南农业大学; 中南民族大学