Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

作者：Carrington Emma M; Zhan Yifan; Brady Jamie L; Zhang Jian Guo; Sutherland Robyn M; Anstee Natasha S; Schenk Robyn L; Vikstrom Ingela B; Delconte Rebecca B; Segal David; Huntington Nicholas D; Bouillet Philippe; Tarlinton David M; Huang David C S; Strasser Andreas; Cory Suzanne; Herold Marco J; Lew Andrew M

来源：Cell Death and Differentiation, 2017, 24(5): 878-888.

DOI：10.1038/cdd.2017.30

Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T cells require BCL-2, while regulatory T cells require MCL-1. Here we examined the survival requirements of multiple immune cell subsets in vitro and in vivo, using both genetic and pharmacological approaches. Our findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins rather than by a single anti-apoptotic protein. This model provides both an insight into how the sum of relative levels of anti-apoptotic proteins BCL-2, MCL-1 and A1 influence survival of T cells, B cells and dendritic cells, and a framework for ascertaining how these different immune cells can be optimally targeted in treatment of immunopathology, transplantation rejection or hematological cancers.

• 出版日期2017-5
• 单位河北医科大学