Aronia berry (Aronia mitschurinii 'Viking') inhibits colitis in mice and inhibits T cell tumour necrosis factor-alpha secretion

作者：Martin Derek A; Smyth Joan A; Liu Zhenhua; Bolling Bradley W^*

来源：Journal of Functional Foods, 2018, 44: 48-57.

DOI：10.1016/j.jff.2018.02.025

• Aronia berry
• Inflammation
• Colitis
• Adoptive transfer
• T cell
• Polyphenol

Aronia berries are rich in polyphenols with anti-inflammatory activity. We hypothesized that amnia berry consumption modulates intestinal immune function and T cells. The aims of the present work were to assess the immunomodulatory potential of 'Viking' aronia berry (black chokeberry, Aronia mitschurinii) in vivo and to determine the extent aroma berry polyphenols or known microbial polyphenol catabolites inhibit T cell tumour necrosis factor (TNF)-alpha in vitro. Amnia berry consumption increased colonic IL-10 secretion in healthy mice, but did not inhibit ex vivo cytokine secretion of lipopolysaccharide-stimulated spleen and colon tissue. Aronia berry consumption inhibited wasting associated with T cell adoptive transfer and dextran sulphate sodium induced colitis. Aronia extracts, neutral phenols fraction, and the polyphenol catabolites 3,4-dihydroxyphenylacetic acid and 3,4-dihydroxyphenylpropionic acid inhibited TNF-alpha production in Jurkat T cells. Therefore, T cells and microbial catabolism partly mediate the anti-inflammatory effects of aronia consumption in the colon.

• 出版日期2018-5