Association of functional polymorphisms in FAS and FAS Ligand genes promoter with pre- eclampsia

作者：Salimi Saeedeh; Moudi Bita^*; Mashhadi Farzaneh Farajian; Tavilani Heidar; Hashemi Mohammad; Zand Hamid; Yaghmaei Minoo

来源：Journal of Obstetrics and Gynaecology Research, 2014, 40(5): 1167-1173.

DOI：10.1111/jog.12327

• FAS
• FAS
• Ligand
• polymorphism
• pre-eclampsia

AimPre-eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FASLigand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS LigandA-670G (rs1800682) and FAS LigandC-844T (rs763110) gene polymorphisms with PE in southeast Iran.
MethodsOne hundred and twenty-seven unrelated women with PE and 139 healthy control subjects were genotyped for the FASA-670G and FAS LigandC-844T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method.
ResultsThe AA, AG and GG genotype frequency of the FASA-670G polymorphism were 21.3%, 53.5% and 25.2% in pre-eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different (P=0.0001). The risk of PE was 2.7- and 4.7-fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS LigandC-844T gene polymorphism was higher in the PE group, the differences were not significant.
ConclusionFAS A-670G polymorphism is associated with a higher risk for PE. There was no association between FAS LigandC-844T polymorphism and PE.

• 出版日期2014-5