科研之友
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摘要
This study was performed to investigate the antioxidant activities of various fractions of Achyranthis radix extract using various solvents in vitro and antioxidant enzyme activities in vivo. Among the various fractions, when n-butanol was used as the extract solvent the DPPH radical scavenge rate was highest at 31.09 mu g/ml. The thiobarbituric acid reaction value using n-butanol fraction was 0.33 at 532 nm after 6 days, representing a decrease of about 42% compared to control group. When the administered concentration of A. radix extract was 400 mg/kg/body weight/day, the xanthine oxidase activity in the liver was 19.5 mU/mg protein, representing a decrease of about 46% compared to the control group. The superoxide dismutase activity in the AR-E2 group was 89.4 Umol/(min mg protein), representing a decrease of about 40% compared to the control group. Catalase and glutathione peroxidase were decreased by about 24% and 58%, respectively, compared to the control group. When n-butanol fraction was used, the nitrite scavenging activity in various fractions at pH 1.2 was highest at 90.2%, an increase of about 90% compared to the control group. The results support the antioxidant potential of A. radix extract for various health supplements, pharmaceuticals, and mutraceuticals.
- 出版日期2009-3
