Disesquiterpene and sesquiterpene coumarins from Ferula pseudalliacea, and determination of their absolute configurations

作者：Dastan Dara; Salehi Peyman^*; Gohari Ahmad Reza; Zimmermann Stefanie; Kaiser Marcel; Hamburger Matthias; Khavasi Hamid Reza; Ebrahimi Samad Nejad

来源：Phytochemistry, 2012, 78: 170-178.

DOI：10.1016/j.phytochem.2012.02.016

• Ferula pseudalliacea
• Apiaceae
• Sesquiterpene coumarin
• ECD
• X-ray analysis
• TDDFT
• Plasmodium falciparum

The first disesquiterpene coumarin, sanandajin, five sesquiterpene coumarins, kamolonol acetate, fekrynol acetate, ethyl galbanate, methyl galbanate, farnesiferol B, and a sesquiterpene, aristolone, were isolated from a n-hexane extract of Ferula pseudalliacea roots. The structures were elucidated by 1D and 2D NMR, HR-ESIMS data, and kamolonol acetate was confirmed by single-crystal X-ray analysis. The absolute configuration of compounds was established by comparison of experimental and simulated ECD spectra using time dependence density function theory (TDDFT). In vitro antiplasmodial activity against Plasmodium falciparum K1 strain was determined. sanandajin, kamolonol acetate and methyl galbanate showed moderate antiplasmodial activity, with IC50 values of 2.6, 16.1 and 7.1 AM, respectively.

• 出版日期2012-6