Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

作者：Ben Ami R^*; Rahav G; Elinav H; Kassis I; Shalit I; Gottesman T; Megged O; Weinberger M; Ciobotaro P; Shitrit P; Weber G; Paz A; Miron D; Oren I; Bishara J; Block C; Keller N; Kontoyiannis D P; Giladi M

来源：Clinical Microbiology and Infection, 2013, 19(8): 752-756.

DOI：10.1111/1469-0691.12004

• Candidaemia
• drug resistance
• epidemiology
• fluconazole

The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with %26gt;600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

• 出版日期2013-8