Determination of N-nitrosodiethanolamine in cosmetic products by headspace solid phase microextraction using a novel aluminum hydroxide grafted fused silica fiber followed by gas chromatography-mass spectrometry analysis

作者：Davarani Saied Saeed Hosseiny^*; Masoomi Leila; Banitaba Mohammad Hossein; Zhad Hamid Reza Lotfi Zadeh; Sadeghi Omid; Samiei Azam

来源：Talanta, 2013, 105: 347-353.

DOI：10.1016/j.talanta.2012.10.053

• N-nitrosodiethanolamine (NDELA)
• Headspace solid phase microextraction
• Cosmetic
• Aluminum hydroxide grafting
• Gas chromatography-mass spectrometry

A method based on headspace solid phase microextraction with a new fiber, coupled with gas chromatography-mass spectrometry was developed for the determination of NDELA in cosmetic samples. The fiber provides Lewis acid-base interaction between its surface and analyte functional groups. The fiber was prepared by grafting aluminum tri-tert-butoxide on the surface of a fused silica. The optimization of SPME conditions showed that NDELA can be most effectively extracted at 70 degrees C, in 15 min, with a sample volume of 0.5 (V-s/V-t), stirring rate of 150 rpm, desorption time of 5 min, desorption temperature of 260 degrees C and at 12.5% (w/w) concentration of NaCl. Under the optimized conditions, LOD of 1 mu g Kg(-1) and a calibration curve with correlation coefficients greater than 0.9897 and a linearity range from 6 to 10000 mu g Kg(-1) were obtained. The intra-day and inter-day precision and accuracy were evaluated at four concentration levels. All of the values for accuracy and precision were lower than the acceptable limit of 15%. The fiber to fiber repeatability was 8.7%. The method was applied for the analysis of real samples including hair shampoo, body shampoo, dishwashing liquid and hand washing liquid. Relative recoveries were achieved in the range of 95-99%.

• 出版日期2013-2-15