A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC-MS with liquid-liquid extraction

作者：Ins*****is Laszlo^*; Angyal Vilmos; Arok Zsofia; Kereszty Eva; Varga Tibor

来源：Forensic Toxicology, 2012, 30(1): 59-65.

DOI：10.1007/s11419-011-0128-z

• Benzoylecgonine
• Liquid-liquid extraction
• Oral fluid
• Blood
• Urine
• GC-MS

The analytical system used for determination of 22 illicit and licit drugs by gas chromatography-mass spectrometry following liquid-liquid extraction has been extended with an additional extraction step with n-butyl acetate:CH2Cl2 = 1:8 to determine benzoylecgonine from the same oral fluid, blood, or urine samples. The extraction recovery of benzoylecgonine was 39.7% for oral fluid, 14.9% for blood, and 26.7% for urine; the cutoffs were 25, 8.0, and 8.0 ng/ml, respectively. The method was fully validated and proved suitable in further proficiency tests and for analysis of 2738 oral fluid, 197 blood, and 1298 urine samples.

• 出版日期2012-1