Adverse drug reactions caused by methotrexate in Saudi population

作者：Al Malaq Haya M; Al Arfaj Hussein F; Al Arfaj Abdurhman S

来源：Saudi Pharmaceutical Journal, 2012, 20(4): 301-305.

DOI：10.1016/j.jsps.2012.05.004

• Methotrexate
• Adverse drug reactions
• Saudi Arabia

Aim: The aim of this study is to document adverse drug reactions (ARDs) of methotrexate (MTX) in Saudi patients. %26lt;br%26gt;Methods: Cross sectional study of adult patients on MTX, attending rheumatology drug monitoring clinics in a university hospital, over a period of 24 weeks. Adverse drug reactions were sought by patient interview, files review and laboratory abnormalities. %26lt;br%26gt;Results: Data collected included patients%26apos; demographics, diagnoses, co-morbidities, MTX dose and duration, other medications, laboratory abnormalities and adverse reactions, their severity, preventability, and outcome. Out of a total of 593 patients screened, 186 (31.4%) using MTX were interviewed. Most of the patients were female (88.5%). Adverse drug reactions (ADRs) were detected in 61 patients (32.8%). Patients with ADRs took a mean dose of 12.9 mg (2.5-22.5 mg). Ten ADRs (16.4% of total reactions) were preventable; they ranged between severe, moderate and mild. The most common ADRs were gastrointestinal (GI) (52.5%), followed by anemia (8.2%) and chest tightness (6.6%). The duration of the reaction ranged from few hours to 4 years. %26lt;br%26gt;Conclusion: In conclusion our patients with adverse reactions were younger, took less medications and had less co-morbidities. Our results were different from those published in the literature relating MTX toxicity.

• 出版日期2012-10