A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia

作者：Zhang, Y.; Zhang, Q.; Che, E. X.; Xia, D. D.; Liu, Y. C.; Li, D.; Zhang, Z. D.; Wang, S. L.^*

来源：Materials Technology, 2015, 30(B4): B211-B215.

DOI：10.1179/17535557B15Y.000000010

• Magnetic particles
• Mesoporous silicon
• Magnetic heat
• Synchronised therapy

A magnetic mesoporous silicon (MMS) composite with magnetic particles as the core and mesoporous as the shell was prepared. The MMS composite was characterised by means of transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption. The MMS composite with the pore-size of 2 and 200 nm in diameter had a good application prospect in the magnetic-induction hyperthermia and drug delivery. The composite function of magnetic-induction hyperthermia was measured by a high-frequency-induction heating machine with the frequency 608 kHz and the field amplitude 6.4 kA m(-1). The magnetic mesoporous composite took about 7 min to heat up 45 degrees C with the average heating rate of 2.25 degrees C min(-1). The function of loading doxorubicin (DOX) hydrochloride was measured at 488 nm on a UV-Vis spectrophotometry, and the loading efficiency with 20.1% was achieved for the DOX hydrochloride being possibly loaded into the mesoporous. This result put MMS a way of the synchronised therapy of hyperthermia and magnetic target drug delivery.

• 出版日期2015
• 单位沈阳药科大学; 中国科学院; 中国科学院金属研究所