A Simple and Economic Synthesis of Propargylamines by CuI-Catalyzed Three-Component Coupling Reaction with Succinic Acid as Additive

作者:Ren Gerui; Zhang Jinli; Duan Zheng; Cui Mengjun; Wu Yangjie*
来源:Australian Journal of Chemistry, 2009, 62(1): 75-81.
DOI:10.1071/CH08086

摘要

A practical and efficient method was developed for the synthesis of propargylamines in a one-pot procedure from aldehydes, amines, and alkynes by using CuI as catalyst and succinic acid as additive. By using this protocol, a wide range of propargylamines was obtained in high yields.