Allosteric Modulators: A Side Door

作者:Abood Mary E*
来源:Journal of Medicinal Chemistry, 2016, 59(1): 42-43.
DOI:10.1021/acs.jmedchem.5b01824

摘要

Allosteric modulators of the cannabinoid CB1 receptor were first discovered in 2005. Since then, although both negative and positive allosteric modulators have been uncovered, many questions remain about their site(s) of action, as well as the basis of their signaling. The described covalent probe with improved potency and efficacy will facilitate these studies.

  • 出版日期2016-1-14