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摘要
PURPOSE: To evaluate the clinical characteristics of beta-parapapillary atrophy (beta-PPA) in myopic eyes and determine whether the microstructure of beta-PPA is associated with parapapillary microvasculature by using optical coherence tomography (OCT) angiography.
DESIGN: Cross-sectional study.
METHODS: This study included 80 subjects with myopia with beta-PPA. Spherical equivalent (SE) refractive error, axial length, horizontal tilt angle, and the width of beta-PPA were evaluated. The microstructure of beta-PPA and subfoveal choroidal thickness were evaluated using enhanced-depth imaging OCT and eyes were classified into 3 groups based on the presence of Bruch membrane (BM): a PPA(+BM)-only group, a PPA(+BM) and PPA(-BM) group, and a PPA(-BM)-only group. Superficial and deep parapapillary vessel density was measured using OCT angiography. Clinical characteristics were compared among the groups and linear regression analysis was performed to explore the relationship between the parapapillary microvasculature and microstructure of beta-PPA.
RESULTS: The mean axial length and SE refractive error of the participants were 26.47 +/- 1.17 mm and -6.28 +/- 2.71 diopters, respectively. The PPA(+BM)-only group had a more inferiorly rotated optic disc (P=.025), larger beta-PPA (P<.001), and lower superficial and deep parapapillary vessel density (both P<.001) compared with those of the PPA(+BM)-only group. Multivariate linear regression analysis showed that the average PPA(+BM) width on horizontal scans was significantly associated with superficial and deep parapapillary vessel density (P=.034 and P=.003, respectively).
CONCLUSIONS: Significant differences were observed in the microvasculature according to the microstructure of beta-PPA. PPA(+BM) width was closely correlated with superficial and deep parapapillary vessel density. Longitudinal studies are needed to elucidate the role of beta-PPA in the development and progression of glaucoma in myopic eyes.
- 出版日期2018-8
- 单位河北医科大学
