New furoquinoline alkaloids from the leaves of Evodia lepta

作者：Sichaem Jirapast; Jirasirichote Apapond; Sapasuntikul Krittakorn; Khumkratok Suttira; Sawasdee Pattara; Thi My Lien Do; Tip Pyang Santi^*

来源：Fitoterapia, 2014, 92: 270-273.

DOI：10.1016/j.fitote.2013.12.002

• Evodia lepta
• Rutaceae
• Furoquinoline alkaloids
• AChE and BChE activities

Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Compound 4 showed the highest inhibitory activity towards BChE with an IC50 value of 47.9 mu M. On the other hand, Compound 5 showed the highest inhibitory activity towards AChE with an IC50 value of 69.1 mu M.

• 出版日期2014-1