Neuroendocrine Response Following a Thoracic Spinal Manipulation in Healthy Men

作者：Sampath Kesava Kovanur^*; Botnmark Erik; Mani Ramakrishnan; Cotter James David; Katare Rajesh; Munasinghe Pujika Emani; Tumilty Steve

来源：Journal of Orthopaedic & Sports Physical Therapy, 2017, 47(9): 617-627.

DOI：10.2519/jospt.2017.7348

• autonomic nervous system
• cortisol
• spinal manipulation
• sympathetic nervous system
• testosterone

STUDY DESIGN: Controlled laboratory study.
BACKGROUND: Spinal manipulation (SM) can trigger a cascade of responses involving multiple systems, including the sympathetic nervous system and the endocrine system, specifically, the hypothalamic-pituitary axis. However, no manual therapy study has investigated the neuroendocrine response to SM (ie, sympathetic nervous system hypothalamic-pituitary axis) in the same trial.
OBJECTIVE: To determine short-term changes in sympathetic nervous system activity, heart rate variability, and endocrine activity (cortisol, testosterone, and testosterone-cortisol [T/C] ratio) following a thoracic SM.
METHODS: Twenty-four healthy men aged between 18 and 45 years were randomized into 2 groups: thoracic SM (n = 12) and sham (n = 12). Outcome measures were salivary cortisol (micrograms per deciliter), salivary testosterone (picograms per milliliter), T/C ratio, heart rate variability, and changes in oxyhemoglobin concentration of the right calf muscle (micromoles per liter). Measurements were done before and at 5 minutes, 30 minutes, and approximately 6 hours after intervention.
RESULTS: A statistically significant group-by time interaction was noted for T/C ratio (P<.05) and salivary cortisol (P<.01) concentrations. Significant between-group differences were noted for salivary cortisol concentration at 5 minutes (mean difference, 0.35; 95% confidence interval: 0.12, 0.6; interaction: P<.01) and for T/C ratio at 6 hours postintervention (mean difference,-0.09; 95% confidence interval:-0.16,-0.04; P=.02). However, SM did not differentially alter oxyhemoglobin, testosterone, or heart rate variability relative to responses in the sham group.
CONCLUSION: Thoracic SM resulted in an immediate decrease in salivary cortisol concentration and reduced T/C ratio 6 hours after intervention. A pattern of immediate sympathetic excitation was also observed in the SM group.

• 出版日期2017-9