A prototype two-partner secretion pathway: the Haemophilus influenzae HMW1 and HMW2 adhesin systems

作者：Geme Joseph W St III^*; Yeo Hye Jeong

来源：Trends in Microbiology, 2009, 17(8): 355-360.

DOI：10.1016/j.tim.2009.06.002

Nontypable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing the upper respiratory tract. Adherence to respiratory epithelium is an important step in the process of colonization and is influenced by adhesive proteins called adhesins. In similar to 80% of nontypable H. influenzae isolates, the major adhesins are related proteins called HMW1 and HMW2. Here, we summarize recent advances in our understanding of HMW1 and HMW2 as prototype members of the bacterial two-partner secretion pathway and examples of the expanding number of bacterial glycoproteins, highlighting experimental approaches that might be useful in studies of other secreted proteins and glycoproteins.

• 出版日期2009-8