A locus for autosomal dominant progressive non-syndromic hearing loss, DFNA27, is on chromosome 4q12-13.1

作者：Peters L M; Fridell R A; Boger E T; Agustin T B San; Madeo A C; Griffith A J; Friedman T B; Morell R J^*

来源：Clinical Genetics, 2008, 73(4): 367-372.

DOI：10.1111/j.1399-0004.2008.00966.x

• DFNA27
• genetic linkage
• inner ear
• non-syndromic hearing loss

We ascertained a large North American family, LMG2, segregating progressive, non-syndromic, sensorineural hearing loss. A genome-wide scan identified significant evidence for linkage (maximum logarithm of the odds (LOD) score = 4.67 at theta = 0 for D4S398) to markers in a 5.7-cM interval on chromosome 4q12-13.1. The DFNA27 interval spans 8.85 Mb and includes at least 61 predicted and 8 known genes. We sequenced eight genes and excluded them as candidates for the DFNA27 gene.

• 出版日期2008-4