Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

作者：Chen, Ying; Fan, Xue-Yun; Jin, Yu-Lan; Yao, San-Qiao; Yun, Xiang; Hua, Zheng-Bing; Shen, Fu-Hai^*

来源：Asian Pacific Journal of Cancer Prevention, 2014, 15(20): 8775-8778.

DOI：10.7314/APJCP.2014.15.20.8775

• Silicosis
• IL-17A, IL-17F
• polymorphism
• disease susceptibility
• combined effect

Background: To explore the relationship between polymorphisms of interleukin 17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. Materials and Methods: A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of AA,GG and AG of IL-17A A-832G locus in the case and control groups were 46.9%, 8.0%, 45.1%, and 49.2%, 7.6%, 43.2%, respectively, with no significant differences (p>0.05). The GG genotype in the IL-17F (7488A/G) locus was not found. The frequencies of AA and GA of IL-17F 7488A/G locus in the case and control groups were 84.1%, 15.9% and 66.4%, 33.6%, respectively (p<0.05). Analysis of combined effects showed that the individuals with GG+AG genotype of IL-17A and GG+GA genotype of IL-17F are protected against silicosis (OR=0.469). Conclusions: IL-17F 7488A/G is associated with susceptibility to silicosis, and G allele may have a protective effect. No relationship was found between IL-17A gene polymorphisms at A-832G and silicosis.

• 出版日期2014
• 单位华北理工大学