Multicentric Osteosarcoma Clinicopathologic and Radiographic Study of 56 Cases

作者：Corradi Domenico; Wenger Doris E; Bertoni Franco; Bacchini Patrizia; Bosio Silvia; Goldoni Matteo; Unni K Krishnan; Sim Franklin H; Inwards Carrie Y^*

来源：American Journal of Clinical Pathology, 2011, 136(5): 799-807.

DOI：10.1309/AJCP0V0OATKCNAZP

• Chemotherapy
• Computed tomography
• Histopathology
• Magnetic resonance imaging
• Metachronous
• Multicentric osteosarcoma
• Prognosis
• Radiographs
• Surgery
• Synchronous

Multicentric osteosarcoma (M-OGS) is characterized by multicentricity of osseous osteosarcomas, either synchronous or metachronous, without visceral involvement. The study's purpose was to clinicopathologically and radiographically analyze 56 cases of M-OGS (22 synchronous and 34 metachronous). The distal femur was the most common site. Histologically, all tumors were high grade. Of 22 patients with synchronous M-OGS, 16 had 3 or more simultaneous tumors; the axial skeleton was involved in 14 (64%) of 22 cases. In metachronous M-OGS, the second malignancy occurred after a median of 22 months. Treatment was surgery, chemotherapy, radiotherapy, or a combination of these. Patients with metachronous osteosarcoma had a median survival longer than did patients with synchronous tumors. Overall, 8 long-term survivors were treated by aggressive surgery with wide margins (plus chemotherapy and/or radiotherapy). M-OGS combines multiple skeletal locations of high-grade conventional osteosarcomas and has a poor prognosis. Aggressive surgery may result in improved long-term survival, particularly in patients with metachronous disease.

• 出版日期2011-11