Autaptic Modulation of Electrical Activity in a Network of Neuron-Coupled Astrocyte

作者：Guo, Shengli; Tang, Jun; Ma, Jun^*; Wang, Chunni

来源：Complexity, 2017, 2017: 4631602.

DOI：10.1155/2017/4631602

• INTRACELLULAR CALCIUM DYNAMICS
• SYNAPTIC-TRANSMISSION
• GLUTAMATE RELEASE
• TIME-DELAY
• IN-SITU
• AUTAPSES
• OSCILLATIONS
• COMMUNICATION
• CELLS
• MODEL

Autapse connection is considered on a biological neuron coupled by astrocyte, and the effect of autapse driving-induced response in electrical activities is investigated. In this paper, a simple network is developed on the Hodgkin-Huxley (HH) neuron coupled by astrocyte and the autapse effect is also considered. The modulation of autapse connected to HH neuron can change the membrane potential by applying time-delayed feedback along a close loop. It is found that the self-adaption of autapse driving can make the network of neuron-astrocyte generate different modes of electrical activities, and oscillating behavior of Ca2+ and IP3 setting is controlled. This new network model can give potential understanding about self-adaption of neuron to external forcing when the coupling of astrocyte and autapse is considered.

• 出版日期2017
• 单位中国矿业大学（北京）; 兰州理工大学