Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba

作者：Qureshi Ahmad Kaleem; Mukhtar Mat Ropi^*; Hiraswa Yusuke; Hosoya Takahiro; Nugroho Alfarius Eko; Morita Hiroshi; Shirota Osamu; Mohamad Khalit; Hadi A Hamid A; Litaudon Marc; Awang Khalijah

来源：Chemical & Pharmaceutical Bulletin, 2011, 59(2): 291-293.

DOI：10.1248/cpb.59.291

• neolamarckine
• indole
• Neolamarckia cadamba
• Rubiaceae
• inducible nitric oxide synthase activity

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

• 出版日期2011-2