Age-dependent alteration of TGF-beta signalling in osteoarthritis

作者:van der Kraan Peter M*; Goumans Marie Jose; Davidson Esmeralda Blaney; ten Dijke Peter
来源:Cell and Tissue Research, 2012, 347(1): 257-265.
DOI:10.1007/s00441-011-1194-6

摘要

Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-beta has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced Smad2/3 phosphorylation, but also via ALK1-induced Smad1/5/8 phosphorylation in articular cartilage. In aging cartilage and experimental OA, the ratio ALK1/ALK5 has been found to be increased, and the expression of ALK1 is correlated with matrix metalloproteinase-13 expression. The age-dependent shift towards Smad1/5/8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.

  • 出版日期2012-1