Anti-inflammatory components of Chrysanthemum indicum flowers

作者：Bui Thi Thuy Luyen; Bui Huu Tai; Nguyen Phuong Thao; Cha Ji Yun; Lee Hoon Yeon; Lee Young Mi^*; Kim Young Ho

来源：Bioorganic & Medicinal Chemistry Letters, 2015, 25(2): 266-269.

DOI：10.1016/j.bmcl.2014.11.054

• Chrysanthemum indicum
• Chrysannol A
• NO
• TNF-alpha
• Anti-inflammation

One new octulosonic acid derivative, chrysannol A (1), along with 17 known compounds (2-18), were isolated from Chrysanthemum indicum flowers. Their structures were determined from 1D NMR, 2D NMR, HR-ESI-MS spectral data, and comparisons with previous reports. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) production by RAW 264.7 cells were investigated. Compound 8 showed the highest inhibition of NO production of 46.09% at a concentration of 10.0 mu M. Compounds 7, 10, 11, and 16 inhibited TNF-alpha secretion at all concentration tested (0.4, 2.0, and 10.0 mu M), with inhibition values ranging from 22.27% to 33.13%. In addition, compound 8 and 9 decrease COX-2 and iNOS protein on Western blot analysis in dose dependent manner.

• 出版日期2015-1-15