Novel CE-MS technique for detection of high explosives using perfluorooctanoic acid as a MEKC and mass spectrometric complexation reagent

作者：Brensinger Karen; Rollman Christopher; Copper Christine; Genzman Ashton; Rine Jacqueline; Lurie Ira; Moini Mehdi^*

来源：Forensic Science International, 2016, 258: 74-79.

DOI：10.1016/j.forsciint.2015.11.007

• High explosives
• CE-MS
• MEKC
• Perfluorooctanoic acid complexation reagent
• Sand analysis

To address the need for the forensic analysis of high explosives, a novel capillary electrophoresis mass spectrometry (CE-MS) technique has been developed for high resolution, sensitivity, and mass accuracy detection of these compounds. The technique uses perfluorooctanoic acid (PFOA) as both a micellar electrokinetic chromatography (MEKC) reagent for separation of neutral explosives and as the complexation reagent for mass spectrometric detection of PFOA-explosive complexes in the negative ion mode. High explosives that formed complexes with PFOA included RDX, HMX, tetryl, and PETN. Some nitroaromatics were detected as molecular ions. Detection limits in the high parts per billion range and linear calibration responses over two orders of magnitude were obtained. For proof of concept, the technique was applied to the quantitative analysis of high explosives in sand samples.

• 出版日期2016-1
• 单位中国人民解放军海军大连舰艇学院