mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC

作者：Nonaka Koichi^*; Fujioka Hikaru; Takii Yasushi; Abiru Seigo; Migita Kiyoshi; Ito Masahiro; Kanematsu Takashi; Ishibashi Hiromi

来源：World Journal of Gastroenterology, 2010, 16(38): 4846-4853.

DOI：10.3748/wjg.v16.i38.4846

• Curative resection
• Hepatocellular carcinoma
• Microsomal prostaglandin E synthase-1
• Non-cancerous liver tissue
• Recurrence-free survival

AIM: To investigate whether microsomal prostaglandin E synthase-1 (mPGES-1) expression in hepatocellular carcinoma (HCC) and in non-cancerous liver affects HCC prognosis after hepatectomy.
METHODS: The relationship between patient clinical profiles, tumor factors, surgical determinants, and mPGES-1 expression and the recurrence-free survival rate were examined in 64 patients who underwent curative hepatectomy between March 2003 and December 2006.
RESULTS: The scores for mPGES-1 expression were higher in well differentiated and moderately differentiated HCC tissues than in poorly differentiated HCC tissues (well differentiated, 5.1 +/- 2.7; moderately differentiated, 5.1 +/- 1.7; poorly differentiated, 3.0 +/- 1.8). In non-cancerous liver tissues, the mPGES-1 levels were higher in injured liver tissues than in normal tissues. Cirrhotic livers had higher mPGES-1 levels than livers with chronic hepatitis (normal livers, 3.3 +/- 0.7; chronic hepatitic livers, 5.4 +/- 1.9; cirrhotic livers, 6.4 +/- 1.6). A univariate analysis revealed that the recurrence-free survival rate was significantly lower in patients with vascular invasion, a higher mPGES-1 level in non-cancerous liver tissue, a larger tumor diameter (>= 5 cm), and a lower serum albumin level (<= 3.7 g/dL). The mPGES-1 expression in HCC tissues did not correlate well with postoperative recurrence. A multivariate analysis demonstrated that the presence of vascular invasion and higher mPGES-1 levels were statistically significant independent predictors for early postoperative recurrence of HCC.
CONCLUSION: Increased mPGES-1 expression in non-cancerous liver tissues is closely associated with the early recurrence of HCC after curative resection.

• 出版日期2010-10-14