Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

作者：Redhu Naresh S; Bakthavatchalu Vasudevan; Conway Evan A; Shouval Dror S; Tsou Amy; Goettel Jeremy A; Biswas Amlan; Wang Chanwu; Field Michael; Muller Werner; Bleich Andre; Li Ning; Gerber Georg K; Bry Lynn; Fox James G; Snapper Scott B; Horwitz Bruce H

来源：eLife, 2017, 6: e27652.

DOI：10.7554/eLife.27652

Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is unknown. Here we show that although signs of colitis are absent in IL10R-deficient mice during the first two weeks of life, intestinal inflammation and macrophage dysfunction begin during the third week of life, concomitant with weaning and accompanying diversification of the intestinal microbiota. However, IL10R did not directly regulate the microbial ecology during infant development. Interestingly, macrophage depletion with clodronate inhibited the development of colitis, while the absence of IL10R specifically on macrophages sensitized infant mice to the development of colitis. These results indicate that IL10R-mediated regulation of macrophage function during the early postnatal period is indispensable for preventing the development of murine colitis.

• 出版日期2017-7-5