Novel organotin(IV) complexes derived from 4-carboxybenzenesulfonamide: Synthesis, structure and in vitro cytostatic activity evaluation

作者：Wang, Shuo; Li, Qian-Li; Zhang, Ru-Fen^*; Du, Ji-Yuan; Li, Yong-Xin; Ma, Chun-Lin^*

来源：Polyhedron, 2019, 158: 15-24.

DOI：10.1016/j.poly.2018.10.048

• Organotin(IV)
• Carboxybenzenesulfonamide
• X-ray crystallography
• Structural characterization
• Cytostatic activity

A new series of 4-carboxybenzenesulfonamide organotin(IV) complexes, [Me3Sn(O2CC6H4-SO2NH2-4)] (<bold>1</bold>), [n-Bu3Sn(O2CC6H4-SO2NH2-4)] (<bold>2</bold>), [Ph3Sn(O2CC6H4-SO2NH2-4)] (<bold>3</bold>), [(Me2Sn)(4)(mu(3)-O)(2)(mu(2)-OCH3)(2)(O2CC6H4-SO2NH2-4)(2)] (<bold>4</bold>), [(n-Bu2Sn)(4)(mu(3)-O)(2)(mu(2)-OCH3)(2)(O2CC6H4-SO2NH2-4)(2)] (<bold>5</bold>), [(n-Oct(2)Sn)(4)(mu(3)-O)(2)(mu(2)-OCH3)(2)(O2CC6H4-SO2NH2-4)(2)] <bold>(6</bold>), have been designed and synthesized from the reactions of 4-carboxybenzenesulfonamide with the corresponding triorganotin(IV) chloride or diorganotin(IV) oxide. The six complexes were characterized by elemental analysis, FT-IR, NMR (H-1, C-13 and Sn-119) spectroscopy, as well as by single crystal X-ray diffraction analysis. X-ray diffraction discloses that complexes <bold>1-</bold>3 represent mononuclear tin(IV) monomer, and complexes <bold>4-</bold>6 adopt tetranuclear tin(IV) ladder-like structure containing two deprotonated ligands linked by three alternate Sn2O2 four-membered rings. Analysis of the non-covalent intermolecular contacts in all complexes reveals the existence of the N-HO=C, N-HO=S and SnO interactions, which play significant function in the supramolecular construction. Furthermore, complexes <bold>1-</bold>5 were evaluated for their in vitro cytostatic activity against human cervical carcinoma cell lines (HeLa) and human hepatocellular carcinoma cell lines (HepG-2). The pilot study has confirmed that some of these novel organotin(IV) complexes exhibited high in vitro cytostatic activity.

• 出版日期2019-1-15
• 单位聊城大学