An efficient one-pot protocol for the synthesis of phenyl substituted 3-silatetrahydropyrans

作者：Kirpichenko Svetlana V^*; Shainyan Bagrat A

来源：Tetrahedron, 2015, 71(4): 599-604.

DOI：10.1016/j.tet.2014.12.037

• Silaheterocycles
• 3-Ph-3-Silatetrahydropyrans
• Intramolecular cyclization
• Electrophilic cleavage of the Ph-Si bond

A new facile and efficient one-pot procedure for the synthesis of 3-phenyl-3-silatetrahydropyrans with an easily functionalized Si-Ph bond was developed. The method is based on the intramolecular cyclization of chloromethyl(3-hydroxypropyl)phenylsilanes using the n-Bu4NBr/i-Pr2NEt combination. As an example of functionalization, the synthesis of the first 3-silatetrahydropyran with an exocyclic RO-Si bond is reported.

• 出版日期2015-1-28