Antiviral activity of 2,3-secotriterpenic hydrazones of the lupane and 19 beta,28-epoxy-18 alpha-oleanane types

作者：Galayko N V; Tolmacheva I A; Grishko V V^*; Volkova L V; Perevozchikova E N; Pestereva S A

来源：Russian Journal of Bioorganic Chemistry, 2010, 36(4): 516-521.

DOI：10.1134/S1068162010040114

• 2,3-secotriterpenoids
• betulonic acid
• allobetulone
• hydrazones
• acylhydrazones
• antiviral activity
• Indiana strain of the vesicular stomatitis virus

Novel hydrazones of the lupane and 19 beta,28-epoxy-18 alpha-oleanane types have been synthesized via the interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of the investigation of the antiviral activity of 2,3-secotriterpenic hydrazones against the Indiana strain of the vesicular stomatitis virus on two models of mammalian cell line infection, the acetylhydrazone of 1-cyano-2,3-seco-19 beta,28-epoxy-18 alpha-olean-3-al has been found to have a high prophylactic activity of 0.00016 mu g/ml to the vesicular stomatitis virus and to inhibit virus reproduction in primarily infected cells in a 0.21-mu g/ml concentration.

• 出版日期2010-7