Activating KIR/HLA complexes in classic Kaposi%26apos;s Sarcoma

作者：Guerini Franca R; Mancuso Roberta; Agostini Simone; Agliardi Cristina; Zanzottera Milena; Hernis Ambra; Tourlaki Athanasia; Calvo Maria G; Bellinvia Monica; Brambilla Lucia; Clerici Mario^*

来源：Infectious Agents and Cancer, 2012, 7: UNSP 9.

DOI：10.1186/1750-9378-7-9

• Kaposi%26apos
• s Sarcoma
• Human Herpesvirus 8
• KSHV
• NK cells
• KIR
• HLA

Background: Classic Kaposi%26apos;s Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. %26lt;br%26gt;Objective: We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. %26lt;br%26gt;Methods: KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. %26lt;br%26gt;Results: There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. %26lt;br%26gt;Conclusion: A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.

• 出版日期2012-4-2