Misclassification of self-reported smoking in adult survivors of childhood cancer

作者：Huang I Chan^*; Klosky James L; Young Chelsea M; Murphy Sharon E; Krull Kevin K; Srivastava DeoKumar; Hudson Melissa M; Robison Leslie L

来源：Pediatric Blood and Cancer, 2018, 65(9): e27240.

DOI：10.1002/pbc.27240

• childhood cancer survivors
• cigarette smoking
• cotinine
• misclassification
• tobacco use

We investigated misclassification rates, sensitivity, and specificity of self-reported cigarette smoking through serum cotinine concentration (liquid chromatography tandem mass spectrometry) among 287 adult survivors of childhood cancer. Overall, 2.5-6.7% and 19.7-36.9% of the self-reported never and past smokers had cotinine levels indicative of active smoking. Sensitivity and specificity of self-reported smoking were 57.5-67.1% and 96.6-99.2%. Misclassification was associated with younger age (OR=3.2; 95% CI=1.4-7.4), male (OR=2.1; 95% CI=1.1-4.0), and past (OR=2.7; 95% CI=1.3-5.8) or current (OR=2.6; 95% CI=1.0-6.6) marijuana use. After adjusting for tobacco-related variables, current marijuana use remained a significant risk for misclassification. Clinicians/researchers should consider bio-verification to measure smoking status among survivors.

• 出版日期2018-9