An Artificial Imine Reductase based on the Ribonuclease S Scaffold

作者：Genz Maika; Koehler Valentin; Krauss Michel; Singer David; Hoffmann Ralf; Ward Thomas R; Straeter Norbert

来源：ChemCatChem, 2014, 6(3): 736-740.

DOI：10.1002/cctc.201300995

• asymmetric catalysis
• half-sandwich complexes
• metalloenzymes
• reduction
• transfer hydrogenation

Dative anchoring of a piano-stool complex within ribonucleaseS resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S-peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.

• 出版日期2014-3