Acute effects of different glycemic index diets on serum motilin, orexin and neuropeptide Y concentrations in healthy individuals

作者：Wu, Hui; Xia, Fang-zhen; Xu, Hui; Zhai, Hua-ling; Zhang, Mei-fang; Zhang, Hui-xin; Li, Yan-xiang; Li, Ying; Gu, Ting; Ma, Li-min; Lu, Ying-li^*

来源：Neuropeptides, 2012, 46(3): 113-118.

DOI：10.1016/j.npep.2012.02.001

• Glycemic index
• Diet
• Motilin
• Orexin
• NPY

Aim: To determine whether different glycemic index (GI) diets have different effects on the acute secretion of motilin, orexin and neuropeptide Y (NPY), regulators of food intake, energy homeostasis and glucose metabolism. @@@ Methods: Fifty healthy volunteers were randomly assigned to two groups and were fed an isocaloric breakfast (464 kcal) containing high GI (HGI; GI = 90) or low GI (LGI; GI = 47) components. Serum motilin, orexin, and NPY concentrations were measured before (0 h) and 2 h after the meal. @@@ Results: The concentrations of motilin, orexin-A, NPY, C-peptide, and blood glucose at Oh were similar in both groups of subjects. However, 2 h after breakfast, the serum motilin, NPY. C-peptide, and blood glucose concentrations were increased and orexin-A concentrations were decreased in both groups. The percentage changes from 0 to 2 h [(2-h value - 0-h value)/baseline x 100)] in motilin (27.72 +/- 2.46% vs. 20.95 +/- 2.06%, p = 0.04) and orexin-A (9.15 +/- 2.06% vs. 3.49 +/- 1.67%, p = 0.038) concentrations were significantly higher in the LGI group than in the HGI group. By contrast, the percentage changes in NPY (53.7 +/- 9.73% vs. 28.1 +/- 5.2%, p = 0.026) and blood glucose (12.3 +/- 3.78% vs. 1.77 +/- 2.52%, p = 0.025) concentrations were significantly greater in the HGI group than in the LGI group. Although C-peptide concentrations increased significantly after breakfast in both groups, the magnitude of the increase was similar (132.69 +/- 25.15% vs. 139.98 +/- 27.29%, p = 0.845). Motilin and NPY concentrations were moderately positive correlated (r = 0.410, p = 0.042), while orexin-A and NPY concentrations were negatively correlated (r = -0.429, p = 0.033) at 2 h in the LGI group. @@@ Conclusions: A breakfast with a LGI reduced the secretion of orexin-A but significantly stimulated motilin secretion, without marked effects on the secretion of NPY. Therefore, consumption of a LGI diet may help to regulate food intake and energy expenditure in healthy individuals based on the changes in these hormones.

• 出版日期2012-6
• 单位上海交通大学