科研之友
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摘要
The palladium-catalyzed reaction of alpha-haloketones with isocyanides afforded alpha-oxo-ketenimines through beta-hydride elimination of the beta-oxo-imidoyl palladium intermediates. Reaction of these relatively stable alpha-oxo-ketenimines with nucleophiles such as hydrazines, hydrazoic acid, amines, and Grignard reagent afforded pyrazoles, tetrazole, beta-keto amidines, and enaminone, respectively, with high chemoselectivity. Whereas amines attack exclusively on the ketenimine functions, the formal [3+2] cycloaddition between N-monosubstituted hydrazines and alpha-oxo-ketenimines was initiated by nucleophilic addition to the carbonyl group.
- 出版日期2017-9-18
