Limited geographic distribution of the novel cyclovirus CyCV-VN

作者：Van Tan Le^*; De Jong Menno D; Nguyen Van Kinh; Nguyen Vu Trung; Taylor Walter; Wertheim Heiman F L; Van der Ende Arie; Van der Hoek Lia; Canuti Marta; Crusat Martin; Sona Soeng; Nguyen Hanh Uyen; Giri Abhishek; Nguyen Thi Thuy Chinh BKrong; Ho Dang Trung Nghia; Farrar Jeremy; Bryant Juliet E; Tran Tinh Hien; Nguyen Van Vinh Chau; Van Doorn H Rogier

来源：Scientific Reports, 2014, 4(1): 3967.

DOI：10.1038/srep03967

A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease.

• 出版日期2014-2-5