Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen

作者：Cheng, Qian; Zhang, Xiaofei; Jiang, Jun^*; Zhao, Guoyang; Wang, Yin; Xu, Youjia^*; Xu, Ximing; Ma, Haile

来源：Biomed Research International, 2017, 2017: 1345193.

DOI：10.1155/2017/1345193

• MECHANICAL-PROPERTIES
• EXTRACELLULAR-MATRIX
• OSTEOPOROSIS
• RISK
• ASSOCIATION
• PREVENTION
• TURNOVER
• FRACTURE
• MARKERS
• CANCER

117 postmenopausal women were divided into Normal, Bone loss (BL), and Osteoporosis group. Compared with Normal group (120.96 +/- 43.18 mu g/L), the serum ferritin (Fer) in BL (223.37 +/- 130.27 mu g/L) and Osteoporosis group (307.50 +/- 161.48.mu g/L) was significantly increased (p < 0.05). Fer level was negatively correlated with BMD (p < 0.01). TRACP levels in Osteoporosis group (4.37 +/- 1.69 U/L) were significantly higher than Normal group (4.10 +/- 1.60 U/L, p < 0.05). ALP levels in Osteoporosis group (112.06 +/- 62.05 U/L) were significantly upregulated compared with Normal group (80.22 +/- 14.94 U/L, p < 0.05) beta-CTX and PINP were the degradation products of type I collagen. beta-CTX levels in Osteoporosis group (667.90 +/- 316.55 ng/L) were significantly increased compared with Normal group (406.06 +/- 112.12 ng/L, p < 0.05). PINP levels inOsteoporosis group (78.03 +/- 37.31.mu g/L) were significantly higher than Normal group (37.60 +/- 13.17. mu g/L, p < 0.01). More importantly, there was a positive correlation between serum Fer and PINP (p < 0.01). Serum Fer showed a positive correlation of serum. beta-CTX (p < 0.01). The overloaded iron improved the degradation of type I collagen.

• 出版日期2017
• 单位江苏大学; 苏州大学; 复旦大学