Association of NET-1 gene expression with human hepatocellular carcinoma

作者：Chen Li; Wang Zhiwei; Zhan Xi; Li De Chuen; Zhu York Yuan; Zhu Jianwei^*

来源：International Journal of Surgical Pathology, 2007, 15(4): 346-353.

DOI：10.1177/1066896907306083

• NET-1
• liver
• carcinoma
• gene expression
• protein expression

NET-1 is a member of the NET-x family. To explore the potential role of NET-1 in hepatocellular carcinoma (HCC), the expression of NET-1 and the relationship with HCC were examined for the first time. We found that NET-1 was frequently expressed in HCC and the peritumor tissue. The relative amounts of NET-I mRNA in HCC and peritumor tissue were 0.645 +/- 0.37 and 0.466 +/- 0.30, respectively, indicating a higher expression level in HCC than in the peritumor (P <.05). NET-1 protein is usually located on the cell membrane and in the cytoplasm of HCC cells. NET-1 immunoreactivity was found in 126 out of 130 samples of HCC tissue (96.92%). An association of NET-I expression with cytological variants, histopathological grading, and clinical stages of HCC was also found (P <.05). Detection of NET-1 gene expression in liver biopsy may provide useful information about the biological behavior of HCC.

• 出版日期2007-10
• 单位南通大学