APOE genotype modifies the association between central arterial stiffening and cognition in older adults

作者：Cambronero Francis E; Liu Dandan; Neal Jacquelyn E; Moore Elizabeth E; Gifford Katherine A; Terry James G; Nair Sangeeta; Pechman Kimberly R; O**orn Katie E; Hohmana Timothy J; Bell Susan P; Sweatt J David; Wang Thomas J; Beckman Joshua A; Carr John Jeffrey; Jefferson Angela L^*

来源：Neurobiology of Aging, 2018, 67: 120-127.

DOI：10.1016/j.neurobiolaging.2018.02.009

• Alzheimer's disease
• Mild cognitive impairment
• Pulse wave velocity
• Cardiac MRI
• Vascular risk factors
• Aging

Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. This study tested the interaction between arterial stiffening and an Alzheimer's disease genetic risk factor (apolipoprotein E [APOE] genotype) on cognition among older adults. Vanderbilt Memory & Aging Project participants with normal cognition (n = 162, 72 +/- 7 years, 29% APOE-epsilon 4 carrier) and mild cognitive impairment (n = 121, 73 +/- 8 years, 42% APOE-epsilon 4 carrier) completed neuropsychological assessment and cardiac MRI to assess aortic stiffening using pulse wave velocity (PWV, m/s). Linear regression models stratified by cognitive diagnosis related aortic PWV x APOE-epsilon 4 status to neuropsychological performances, adjusting for demographic and vascular risk factors. PWV x APOE-epsilon 4 related to poorer performance on measures of lexical retrieval (beta = 0.29, p = 0.01), executive function (beta = 0.44, p = 0.02), and episodic memory (beta = 3.07, p = 0.02). Among participants with higher aortic PWV, APOE-e4 modified the association between central arterial stiffening and cognition, such that carriers had worse performances than noncarriers. Findings add to a growing body of evidence for APOE-vascular interactions on cognition in older adults and warrant further research into less heart-healthy cohorts where the association between PWV and cognition among older adults might be stronger.

• 出版日期2018-7