科研之友
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摘要
Ethnopharmacological relevance: Type 2 diabetes is characterized by tissue resistance to the action of insulin combined with a relative deficiency in insulin secretion. In Mexico, medicinal plants have traditionally been used to control the disease; in this work, we investigate the hypoglycemic effect of Ageratina petiolaris, a plant used in Mexico for the treatment of diabetes. Methods: The hypoglycemic effects of aqueous and methanolic extracts prepared from aerial parts of Ageratina petiolaris in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats were assessed. An oral administration of the water extract at doses of 40 and 160 mg/kg and of the methanol extract at doses of 67 and 268 mg/kg were evaluated. Furthermore, the water extract at 160 mg/kg was evaluated under an Oral Glucose Tolerance Test. Results: The tested extracts were able to reduce the increase in blood glucose level at three hours after administration. L-chiro-inositol and chlorogenic acid were isolated as important constituents of the plant, they were identified in both extracts along with other constituents. Conclusions: The results presented here demonstrate that the main components in the aqueous extract of Ageratina petiolaris are chlorogenic acid and L-chiro-inositol, the last one with significant hypoglycemic activity, these results support the traditional use of this plant for the treatment of type 2 diabetes.
- 出版日期2016-6-5
