Mechanostability of cohesin-dockerin complexes in a structure-based model: Anisotropy and lack of universality in the force profiles

作者：Wojciechowski Michal^*; Thompson Damien; Cieplak Marek

来源：Journal of Chemical Physics, 2014, 141(24): 245103.

DOI：10.1063/1.4904726

We use a structure-based coarse grained model to elucidate stretching of three cohesin-dockerin complexes that are found in the cellulosome. The average strength of mechanostability is comparable to that of the I27 domain of titin, but the force profiles depend on the pulling direction and anisotropy effects can be substantial. Even though the force profiles for individual cohesins and dockerins are similar, those for their complexes are visibly distinct for any pulling direction.

• 出版日期2014-12-28