科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Few data exist regarding anti-Mullerian hormone, a marker of ovarian reserve, in relation to environmental factors with potential ovarian toxicity. Methods: This analysis included 420 women from Limpopo, South Africa studied in 2010-2011. Women were administered comprehensive questionnaires, and plasma concentrations of anti-Mullerian hormone and dichlorodiphenyltrichloroethane were determined. We used separate multivariable models to examine the associations between natural log-transformed anti-Mullerian hormone concentration (ng/ml) and each of the lifestyle, reproductive, and environmental factors of interest, adjusted for age, body mass index, education, and parity. Results: The median age of women was 24 years (interquartile range [IQR] - 22 to 26); the median anti-Mullerian hormone concentration was 3.1 ng/ml (IQR - 2.0 to 6.0). Women who reported indoor residual spraying in homes with painted walls (indicative of exposure to pyrethroids) had 25% lower (95% confidence interval [CI] = -39%, -8%) anti-Mullerian hormone concentrations compared with women who reported no spraying. Little evidence of decreased anti-Mullerian hormone concentrations was observed among women with the highest dichlorodiphenyltrichloroethane levels. Compared with women who used an electric stove, no association was observed among women who cooked indoors over open wood fires. The findings also suggested lower anti-Mullerian hormone concentrations among women who drank coffee (-19% [95% CI = -31%, -5%]) or alcohol (-21% [95% CI = -36%, -3%]). Conclusions: These are among the first data regarding anti-Mullerian hormone concentrations relative to pesticides and indoor air pollution. Our results are suggestive of decreased ovarian reserve associated with exposure to pyrethroid pesticides, which is consistent with laboratory animal data.
- 出版日期2015-5
